Medina M, Urdiales J L, Amores-Sánchez M I
Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Spain.
Eur J Biochem. 2001 Jul;268(14):3871-82. doi: 10.1046/j.1432-1327.2001.02278.x.
Mild hyperhomocysteinemia has been suggested as a new, independent risk factor for cardiovascular disease. This fact has produced a new, increased interest in the study of homocysteine metabolism and its relation to pathogenesis. This emergent area of biomedical research is reviewed here, stressing the biochemical and metabolic basis of the pathogenicity of increased levels of homocysteine.
轻度高同型半胱氨酸血症已被认为是心血管疾病的一个新的独立危险因素。这一事实引发了对同型半胱氨酸代谢及其与发病机制关系研究的新的、更大的兴趣。本文对这一新兴的生物医学研究领域进行综述，着重阐述同型半胱氨酸水平升高致病变的生化和代谢基础。
