Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha, 410125, Hunan, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
Amino Acids. 2018 Jan;50(1):3-9. doi: 10.1007/s00726-017-2503-5. Epub 2017 Oct 10.
Hyperhomocysteinemia is an independent risk factor for cardiovascular disease and is associated with primary causes of mortality and morbidity throughout the world. Several studies have been carried out to evaluate the effects of a diet inducing cystathionine-β-synthase, methyltetrafolate, folic acid, and vitamin B supplemented with methionine on the homocysteine metabolism and in lowering the plasma total homocysteine levels. A large number of molecular and biomedical studies in numerous animals, such as mice, rabbits, and pigs, have sought to elevate the plasma total homocysteine levels and to identify a disease model for human hyperhomocysteinemia. However, a specific animal model is not suitable for hyperhomocysteinemia in terms of all aspects of cardiovascular disease. In this review article, the experimental progress of animal models with plasma total homocysteine levels is examined to identify a feasible animal model of hyperhomocysteinemia for different aspects.
高同型半胱氨酸血症是心血管疾病的独立危险因素，与世界各地的主要死亡和发病原因有关。已经进行了几项研究来评估饮食诱导胱硫醚-β-合酶、甲基四氢叶酸、叶酸和维生素 B 补充蛋氨酸对同型半胱氨酸代谢和降低血浆总同型半胱氨酸水平的影响。大量的分子和生物医学研究在许多动物，如老鼠、兔子和猪，试图提高血浆总同型半胱氨酸水平，并确定人类高同型半胱氨酸血症的疾病模型。然而，就心血管疾病的所有方面而言，特定的动物模型并不适合高同型半胱氨酸血症。在这篇综述文章中，检查了具有血浆总同型半胱氨酸水平的动物模型的实验进展，以确定不同方面的可行的高同型半胱氨酸血症动物模型。
