Meredith S, Feldman P H, Frey D, Hall K, Arnold K, Brown N J, Ray W A
Department of Preventive Medicine, Division of Pharmacoepidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
J Am Geriatr Soc. 2001 Jun;49(6):719-24. doi: 10.1046/j.1532-5415.2001.49147.x.
To determine the frequency of possible medication errors in a population of older home healthcare patients according to expert panel objective criteria.
A cross-sectional survey.
Two of the largest urban home healthcare agencies in the United States.
Home healthcare patients age 65 and older admitted to selected offices of these agencies between October 1996 and September 1998.
We used two sets of consensus-based expert panel criteria to define possible medication errors. The Home Health Criteria identify patients with patterns of medication use and signs and symptoms that indicate sufficient likelihood of a medication-related problem to warrant reevaluating the patient. The Beers criteria identify medications that experts have deemed generally inappropriate for older patients.
The 6,718 study subjects took a median of five drugs; 19% were taking nine or more medications. A possible medication error was identified for 19% of patients according to Home Health Criteria, 17% according to the Beers criteria, and 30% according to either. Possible errors increased linearly with number of medications taken. When patients taking one to three medications were compared with those taking nine or more drugs, the percentages with possible errors were, respectively, 10% and 32% for the Home Health Criteria, 8% and 32% for the Beers criteria, and 16% and 50% for both.
Nearly one-third of the home healthcare patients surveyed had evidence of a potential medication problem or were taking a drug considered inappropriate for older people. More-effective methods are needed to improve medication use in this vulnerable population.
根据专家小组的客观标准,确定老年家庭医疗患者群体中可能出现用药错误的频率。
横断面调查。
美国两家最大的城市家庭医疗机构。
1996年10月至1998年9月期间,这些机构选定办公室收治的65岁及以上的家庭医疗患者。
我们使用了两套基于共识的专家小组标准来定义可能的用药错误。家庭健康标准用于识别有用药模式以及体征和症状的患者,这些表明存在与药物相关问题的可能性足够大,值得对患者进行重新评估。Beers标准用于识别专家认为一般不适用于老年患者的药物。
6718名研究对象服用药物的中位数为5种;19%的人服用9种或更多药物。根据家庭健康标准,19%的患者被确定存在可能的用药错误;根据Beers标准,这一比例为17%;根据任何一套标准,这一比例为30%。可能的错误随着服用药物数量的增加呈线性增加。将服用1至3种药物的患者与服用9种或更多药物的患者进行比较时,家庭健康标准下可能出现错误的百分比分别为10%和32%,Beers标准下为8%和32%,两套标准下均为16%和50%。
近三分之一接受调查的家庭医疗患者有潜在用药问题的证据,或者正在服用被认为不适用于老年人的药物。需要更有效的方法来改善这一弱势群体的用药情况。