阿加曲班的简短合成，一种强效的选择性凝血酶抑制剂。
A short synthesis of argatroban. a potent selective thrombin inhibitor.
作者信息
Cossy J, Belotti D
机构信息
Laboratoire de Chimie Organique associé au CNRS, ESPCI, 10 rue Vauquelin, 75231 Cedex 05, Paris, France.
出版信息
Bioorg Med Chem Lett. 2001 Aug 6;11(15):1989-92. doi: 10.1016/s0960-894x(01)00351-1.
Abstract
Argatroban was synthesized in seven steps from 4-methylpiperidine. The condensation of (+/-)-trans-benzyl 4-methylpipecolic acid ester with N(alpha)-Boc-N(omega)-nitro-L-arginine led to two diastereomers that were separated. One of them is the precursor of argatroban.
摘要
阿加曲班由4-甲基哌啶经七步合成。（±）-反式苄基4-甲基哌啶酸酯与N（α）-Boc-N（ω）-硝基-L-精氨酸缩合产生两种非对映异构体，它们被分离。其中之一是阿加曲班的前体。
Zotero 插件