高选择性EP4受体激动剂的设计与合成。第1部分：具有高选择性的3,7-二硫杂PG衍生物。
Design and synthesis of a highly selective EP4-receptor agonist. Part 1: 3,7-dithiaPG derivatives with high selectivity.
作者信息
Maruyama T, Asada M, Shiraishi T, Ishida A, Egashira H, Yoshida H, Maruyama T, Ohuchida S, Nakai H, Kondo K, Toda M
机构信息
Minase Research Institute, Ono Pharmaceutical Co., Ltd., Shimamoto, Mishima, 618-8585, Osaka, Japan.
出版信息
Bioorg Med Chem Lett. 2001 Aug 6;11(15):2029-31. doi: 10.1016/s0960-894x(01)00364-x.
Abstract
A series of 3,7-dithiaPGE(1) analogues 3, 4, 11, 16 and 19 were identified as highly selective EP4-receptor agonists starting from the chemical modification of 7-thiaPGE(1) analogue 1. EP4-receptor selectivity and agonist activity were maximized in 3 and 4.
摘要
从7-硫杂前列地尔类似物1的化学修饰开始，一系列3,7-二硫杂前列地尔类似物3、4、11、16和19被鉴定为高选择性EP4受体激动剂。EP4受体选择性和激动剂活性在3和4中达到最大值。
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