高选择性EP4受体激动剂的设计与合成。第2部分：具有改善稳定性的5-硫杂和9β-卤代前列腺素衍生物。
Design and synthesis of a highly selective EP4-receptor agonist. Part 2: 5-thia and 9beta-haloPG derivatives with improved stability.
作者信息
Maruyama T, Asada M, Shiraishi T, Sakata K, Seki A, Yoshida H, Shinagawa Y, Maruyama T, Ohuchida S, Nakai H, Kondo K, Toda M
机构信息
Minase Research Institute, Ono Pharmaceutical Co., Ltd., Shimamoto, Mishima, 618-8585, Osaka, Japan.
出版信息
Bioorg Med Chem Lett. 2001 Aug 6;11(15):2033-5. doi: 10.1016/s0960-894x(01)00365-1.
Abstract
Further chemical modification to identify more chemically stabilized EP4-receptor selective agonists was continued. As a result, a further two EP4-receptor selective agonists 5-thiaPGE(1) 2a, 10 and 9beta-chloroPGF(2) analogue 11 were discovered.
摘要
继续进行进一步的化学修饰以鉴定更多化学稳定的EP4受体选择性激动剂。结果，又发现了另外两种EP4受体选择性激动剂5-硫代PGE(1) 2a、10和9β-氯PGF(2)类似物11。
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