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促甲状腺激素释放激素（TRH）对人体在基础状态下以及服用甲基麦角新碱后促甲状腺激素（TSH）、催乳素（PRL）和生长激素（GH）释放的影响。

The effect of TRH on the release of TSH, PRL and GH in man under basal conditions and following methysergide.

作者信息

Collu R

出版信息

J Endocrinol Invest. 1978 Apr;1(2):121-4. doi: 10.1007/BF03350358.

DOI:10.1007/BF03350358
PMID:114568
Abstract

Pretreatment with methysergide, a blocker of serotoninergic receptors, significantly reduced the TSH response to TRH in six male volunteers. The TRH-induced PRL release was also slightly decreased, while plasma GH levels were not significantly modified by TRH either during the control period or after methysergide. These results indicate that alterations of central nervous system monoaminergic pathways may modify the hypophysiotropic effects of TRH.

摘要

对六名男性志愿者进行预处理，使用血清素能受体阻滞剂美西麦角，可显著降低促甲状腺激素对促甲状腺激素释放激素（TRH）的反应。TRH诱导的催乳素释放也略有下降，而在对照期或使用美西麦角后，TRH对血浆生长激素水平均无显著影响。这些结果表明，中枢神经系统单胺能途径的改变可能会改变TRH的促垂体作用。

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本文引用的文献

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A SENSITIVE DOUBLE ANTIBODY IMMUNOASSAY FOR HUMAN GROWTH HORMONE IN PLASMA.血浆中人生长激素的一种灵敏双抗体免疫测定法。
Nature. 1964 Sep 12;203:1141-2. doi: 10.1038/2031141a0.
2
Increased serum prolactin after administration of synthetic thyrotropin releasing hormone (TRH) in man.人体注射合成促甲状腺激素释放激素（TRH）后血清催乳素升高。
J Clin Endocrinol Metab. 1971 Dec;33(6):996-8. doi: 10.1210/jcem-33-6-996.
3
Prolactin and thyrotropin release in man by synthetic pyroglutamyl-histidyl-prolinamide.合成焦谷氨酰-组氨酰-脯氨酰胺对人催乳素和促甲状腺激素释放的影响
Biochem Biophys Res Commun. 1971 Nov;45(4):1033-41. doi: 10.1016/0006-291x(71)90441-4.
4
Inhibition of hypoglycemia-induced growth hormone secretion by the serotonin antagonists cyproheptadine and methysergide.血清素拮抗剂赛庚啶和甲基麦角新碱对低血糖诱导的生长激素分泌的抑制作用。
N Engl J Med. 1973 Aug 2;289(5):236-9. doi: 10.1056/NEJM197308022890503.
5
A homologous radioimmunoassay for human prolactin.一种用于人催乳素的同源放射免疫测定法。
J Clin Endocrinol Metab. 1973 Mar;36(3):509-16. doi: 10.1210/jcem-36-3-509.
6
Abnormalities in the release of TSH in response to thyrotropin-releasing hormone (TRH) in patients with disorders of the pituitary, hypothalamus and basal ganglia.垂体、下丘脑和基底神经节疾病患者对促甲状腺激素释放激素（TRH）反应中促甲状腺激素（TSH）释放的异常。
J Clin Endocrinol Metab. 1972 Oct;35(4):609-15. doi: 10.1210/jcem-35-4-609.
7
Increase of serum growth hormone concentration following thyrotropin-releasing hormone injection in patients with acromegaly or gigantism.肢端肥大症或巨人症患者注射促甲状腺激素释放激素后血清生长激素浓度的升高。
J Clin Endocrinol Metab. 1972 Jul;35(1):97-100. doi: 10.1210/jcem-35-1-97.
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