Papakostas Y G, Markianos M, Papadimitriou G N, Zervas I M, Stefanis C N
Department of Psychiatry, Athens University Medical School, Greece.
Eur Neuropsychopharmacol. 1995 Mar;5(1):15-8. doi: 10.1016/0924-977x(94)00126-v.
Despite extensive study of the effects of various pharmacological agents on the thyrotropin (TSH) and prolactin (PRL) responses to TRH challenge, the effect of serotoninergic agents remains inconclusive. We studied the effect of the serotonin antagonists methysergide (non-selective 5-HT1/5-HT2 blocker with dopaminergic properties) and ritanserin (selective 5-HT2 blocker) on the TSH and PRL responses to TRH stimulation in two groups of medication-free female depressed patients in a double-blind, within-subject design. Methysergide was found to decrease significantly the PRL response to TRH, while ritanserin had no effect. Neither compound influenced the TSH response. Results suggest that 5-HT2 mechanisms do not mediate the PRL and TSH responses to TRH challenge in depression. The reduction in PRL observed after methysergide is probably due to either 5-HT1 or dopaminergic mechanisms.
尽管对各种药理剂对促甲状腺激素（TSH）和催乳素（PRL）对促甲状腺激素释放激素（TRH）激发反应的影响进行了广泛研究，但血清素能药剂的作用仍无定论。我们采用双盲、受试者自身对照设计，研究了血清素拮抗剂美西麦角（具有多巴胺能特性的非选择性5-HT1/5-HT2阻滞剂）和利坦色林（选择性5-HT2阻滞剂）对两组未服用药物的女性抑郁症患者TSH和PRL对TRH刺激反应的影响。发现美西麦角能显著降低PRL对TRH的反应，而利坦色林无此作用。两种化合物均未影响TSH反应。结果表明，5-HT2机制不介导抑郁症患者PRL和TSH对TRH激发的反应。美西麦角后观察到的PRL降低可能是由于5-HT1或多巴胺能机制。
