泼尼松对甲状腺功能减退患者血清促甲状腺激素、甲状腺素和三碘甲状腺原氨酸浓度的影响。

The effect of prednisone on serum thyrotropin, thyroxine and triiodothyronine concentrations in hypothyroid patients.

作者信息

Jensen J, Nolan G, Jubiz W

出版信息

J Endocrinol Invest. 1978 Apr;1(2):171-3. doi: 10.1007/BF03350367.

Abstract

The effect of exogenous prednisone on serum thyrotropin (TSH), thyroxine (T4), and triiodothyronine (T3) concentrations was investigated in four patients with non-functioning thyroid glands receiving T4 replacement therapy. Orally administered prednisone, in a dose of 20 mg each day for nine days, resulted in a significant decrease in mean serum TSH levels (p less than 0.01) without significant changes in levels of serum T4, T3, and thyroxine binding globulin (TBG). These findings suggest an inhibitory action of relatively low pharmacologic doses of prednisone on TSH release without changes in circulating thyroid hormone concentrations or inhibition of the peripheral conversion of T4 to T3.

摘要

在4例接受甲状腺素替代治疗的无功能性甲状腺患者中，研究了外源性泼尼松对血清促甲状腺激素（TSH）、甲状腺素（T4）和三碘甲状腺原氨酸（T3）浓度的影响。口服泼尼松，剂量为每天20 mg，共9天，导致血清TSH平均水平显著降低（p<0.01），而血清T4、T3和甲状腺素结合球蛋白（TBG）水平无显著变化。这些发现提示，相对低药理剂量的泼尼松对TSH释放有抑制作用，而不改变循环甲状腺激素浓度或抑制T4向T3的外周转化。