锂对人脑磷酸肌醇代谢的影响：一项质子去耦（31）P磁共振波谱研究。
Effect of lithium on phosphoinositide metabolism in human brain: a proton decoupled (31)P magnetic resonance spectroscopy study.
作者信息
Yildiz A, Demopulos C M, Moore C M, Renshaw P F, Sachs G S
机构信息
Dokuz Eylul Medical School, Department of Psychiatry, Izmir, Turkey.
出版信息
Biol Psychiatry. 2001 Jul 1;50(1):3-7. doi: 10.1016/s0006-3223(01)01069-1.
BACKGROUND
The objective of our study was to evaluate whether lithium increases brain phosphomonoester (PME) levels in human subjects.
METHODS
Proton decoupled (31)P magnetic resonance spectra were obtained from eight healthy volunteers before and after the administration of lithium carbonate, 450 mg b.i.d., for 7 and 14 days.
RESULTS
Pairwise comparisons of the mole percent PME revealed a significant increase from baseline at day 7 and day 14 of lithium administration.
CONCLUSIONS
An increase in PME concentration with 7 and 14 days of lithium administration in the human brain in vivo was observed. Because the inositol-1-monophosphate contributes to the PME peak, this result suggests that some of the initial actions of lithium may occur through a reduction of myo-inositol, which in turn may initiate a cascade of secondary changes at different levels of signal transduction process and gene expression in brain, effects that are ultimately responsible for the therapeutic benefits of lithium.
背景
我们研究的目的是评估锂是否会增加人体大脑中的磷酸单酯（PME）水平。
方法
在8名健康志愿者服用碳酸锂（450毫克，每日两次）7天和14天前后，获取质子去耦（31）P磁共振波谱。
结果
PME摩尔百分比的成对比较显示，在锂给药的第7天和第14天，与基线相比有显著增加。
结论
观察到在人体内，锂给药7天和14天后，大脑中PME浓度增加。由于肌醇-1-单磷酸对PME峰有贡献，该结果表明锂的一些初始作用可能通过肌醇的减少而发生，这反过来可能在大脑信号转导过程和基因表达的不同水平引发一系列继发性变化，这些效应最终导致锂的治疗益处。
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