Kato T, Shioiri T, Takahashi S, Inubushi T
Department of Psychiatry, Shiga University of Medical Science, Otsu, Japan.
J Affect Disord. 1991 Aug;22(4):185-90. doi: 10.1016/0165-0327(91)90064-y.
In vivo phosphorus-31 magnetic resonance spectroscopy (31P-MRS) was used to measure phosphorus metabolism in the brains of manic patients treated with lithium carbonate. The phosphomonoester (PME) peak was elevated in the manic state in patients with DSM-IIIR bipolar disorder compared to the euthymic state and to drug-free normal controls. Elevation of the PME peak may be caused by lithium-induced accumulation of inositol 1-phosphate in the brain.
采用体内磷-31磁共振波谱法（31P-MRS）测量碳酸锂治疗的躁狂症患者大脑中的磷代谢。与心境正常状态及未服药的正常对照组相比，DSM-IIIR双相情感障碍患者在躁狂状态下磷酸单酯（PME）峰升高。PME峰升高可能是由锂诱导大脑中肌醇1-磷酸蓄积所致。
