锂对人脑海苷三磷酸水平的影响：一项质子去耦31P磁共振波谱研究。

Lithium-induced alterations in nucleoside triphosphate levels in human brain: a proton-decoupled 31P magnetic resonance spectroscopy study.

作者信息

Yildiz Aysegul, Moore Constance M, Sachs Gary S, Demopulos Christina M, Tunca Zeliha, Erbayraktar Zubeyde, Renshaw Perry F

机构信息

Dokuz Eylul Medical School, Department of Psychiatry, Izmir, Turkey.

出版信息

Psychiatry Res. 2005 Jan 30;138(1):51-9. doi: 10.1016/j.pscychresns.2003.10.005.

DOI:10.1016/j.pscychresns.2003.10.005

PMID:15708301

Abstract

We examined how lithium's demonstrated effects on various cellular processes in human brain would be reflected in the (31)P magnetic resonance spectra of living human beings with respect to brain high-energy phosphate metabolites. Eight healthy volunteers received a baseline (31)P magnetic resonance spectroscopy (MRS) scan, after which they received lithium carbonate, 900 mg/day, for 14 days. Follow-up MRS scans were obtained on day 7 and on day 14. We detected a lithium-induced decrease in alpha-, beta-, gamma- and total nucleoside triphosphate NTP levels with chronic administration of lithium. On day 7, significant decreases were noted in gamma-NTP (14%) and total NTP (11%) levels. There was a trend for a decrease in beta-NTP (11%) levels. On day 14, significant decreases were noted in alpha-NTP (7%) and total NTP (8%) levels. There was a trend for a decrease in beta-NTP (16%) levels. Lithium caused a 25% reduction in inorganic phosphate (P(i)) levels on day 14. The theoretical relevance of the lithium-induced alterations on brain high-energy phosphates to the lithium-induced modifications of neuroplasticity is discussed.

摘要

我们研究了锂对人类大脑各种细胞过程的已证实作用，将如何在活体人类的（31）P磁共振波谱中，就脑高能磷酸代谢物方面得到体现。八名健康志愿者接受了一次基线（31）P磁共振波谱（MRS）扫描，之后他们每天服用900毫克碳酸锂，持续14天。在第7天和第14天进行了后续的MRS扫描。我们检测到，长期服用锂会导致α -、β -、γ -和总核苷三磷酸（NTP）水平下降。在第7天，γ - NTP水平显著下降了14%，总NTP水平显著下降了11%。β - NTP水平有下降趋势（11%）。在第14天，α - NTP水平显著下降了7%，总NTP水平显著下降了8%。β - NTP水平有下降趋势（16%）。在第14天，锂使无机磷酸盐（P(i)）水平降低了25%。本文讨论了锂诱导的脑高能磷酸盐变化与锂诱导的神经可塑性改变之间的理论相关性。