Milutina N A, Nekhliudova M Ia
Tsitologiia. 1975 Feb;17(2):163-6.
The quantitative ratio between labelled pre-and postmitotic nuclei of hepatocytes was studied 8 hr after H-3-thymidine administration in the 12-15 g mice. The karyoautoradiographic analysis showed that DNA-synthetizing cells are concentrated at a certain stage of S-period. This indicates the complete synchronization of DNA synthesis in the liver parenchyma. The times during which all the hepatocytes enter the S-period did not exceed 4 hr.
在给12 - 15克重的小鼠注射H - 3 - 胸腺嘧啶核苷8小时后,研究了肝细胞有丝分裂前和有丝分裂后标记细胞核之间的定量比率。核放射自显影分析表明,DNA合成细胞集中在S期的某个阶段。这表明肝实质中DNA合成完全同步。所有肝细胞进入S期的时间不超过4小时。