Salmi S, Santti R, Gustafsson J A, Mäkelä S
Institute of Biomedicine, University of Turku, Turku, Finland.
J Urol. 2001 Aug;166(2):674-7.
Androgens and estrogens influence voiding. In this study their target sites in the lower urinary tract of the male rat were identified.
Cryosections of the bladder body, bladder neck, prostatic urethra, mid proximal urethra and prostatic autonomic ganglia of adult male rats were immunostained with specific estrogen receptor alpha, estrogen receptor beta (ERbeta) or androgen receptor (AR) antibodies. The sections were then examined under conventional, fluorescence or confocal fluorescence microscopy.
Co-expression of AR and ERbeta in the urothelium, bladder smooth muscle cells, proximal urethra striated muscle cells and neurons in the autonomic ganglia of the prostatic plexus suggests that estrogen and androgen have direct effects in the lower urinary tract.
The local interaction of AR and ERbeta in the hormonal control of voiding is an intriguing possibility.
雄激素和雌激素会影响排尿。在本研究中，确定了它们在雄性大鼠下尿路中的靶位点。
用特异性雌激素受体α、雌激素受体β（ERβ）或雄激素受体（AR）抗体对成年雄性大鼠的膀胱体、膀胱颈、前列腺尿道、尿道中近端和前列腺自主神经节的冰冻切片进行免疫染色。然后在常规、荧光或共聚焦荧光显微镜下检查切片。
AR和ERβ在尿路上皮、膀胱平滑肌细胞、尿道近端横纹肌细胞以及前列腺丛自主神经节的神经元中共同表达，这表明雌激素和雄激素在下尿路具有直接作用。
AR和ERβ在排尿激素控制中的局部相互作用是一种有趣的可能性。
