Lukits J, Timár J, Juhász A, Döme B, Paku S, Répássy G
1st Institute of Pathology and Experimental Cancer Research, Budapest, Hungary.
Otolaryngol Head Neck Surg. 2001 Jul;125(1):18-22. doi: 10.1067/mhn.2001.116187.
A recent survey of head and neck cancer indicated a sharp difference in survival between cancer of the hypopharynx and cancers formed in other head and neck sites. We have analyzed tumor size relative to clinical stage and vascularization as possible causes for such a difference in a series of 21 patients with cancer of the laryngopharynx (11 glottic and 10 hypopharyngeal). We found that the volume of the smallest cancers of the larynx at stage 2 is significantly larger than the volume of the cancers of the hypopharynx at stage 4 (P < 0.05). Next, we have determined by immunohistochemistry and morphometry the microvessel density, microvessel perimeter, and vascular endothelial growth factor (VEGF) expression of laryngo-hypopharyngeal cancers. Analysis of these data indicates that there is no difference in vascularization and VEGF expression between these two tumor types. These data strongly suggest that the invasive but not the angiogenic phenotype of hypopharyngeal cancer cells could be responsible for the more aggressive biologic behavior of this head and neck cancer subtype.
最近一项关于头颈癌的调查表明，下咽癌与其他头颈部位形成的癌症在生存率上存在显著差异。我们分析了21例喉咽癌患者（11例声门癌和10例下咽癌）的肿瘤大小与临床分期及血管形成情况，以此作为造成这种差异的可能原因。我们发现，2期喉癌最小肿瘤的体积显著大于4期下咽癌肿瘤的体积（P < 0.05）。接下来，我们通过免疫组织化学和形态学测定了喉咽癌的微血管密度、微血管周长和血管内皮生长因子（VEGF）表达。对这些数据的分析表明，这两种肿瘤类型在血管形成和VEGF表达方面没有差异。这些数据有力地表明，下咽癌细胞的侵袭性而非血管生成表型可能是导致这种头颈癌亚型具有更强侵袭性生物学行为的原因。
