Muzyka B C, Kamwendo L, Mbweza E, Lopez N B, Glick M, Matheson P B, Kershbaumer R, Nyrienda T, Malamud D, Constantine N T, Thompson J, Nyasulu Y, Saville R, Berthold P
WHO Collaborating Center in Oral Infectious Diseases, University of Pennsylvania School of Dental Medicine, Philadelphia., University of Pennsylvania School of Dental Medicine, Philadelphia, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Jul;92(1):56-61. doi: 10.1067/moe.2001.112542.
Whether oral lesions were associated with human immunodeficiency virus-type 1 (HIV-1) status in a cohort of pregnant Malawian women was studied.
Six hundred thirty-eight women participated in a randomized prospective study at 3 prenatal clinics in a rural area of southern Malawi. Oral examinations, followed by collection of oral fluid specimens with an HIV-1 oral specimen collection device, were performed. The specimens were tested for antibodies against HIV-1.
Sixty-one oral lesions were found in 60 participants. While traditional HIV-1 associated lesions were rare, benign migratory glossitis was unexpectedly common (6%). Oral hairy leukoplakia was significantly more common among women who were HIV-1 positive than among women who were HIV-1 negative. An HIV-1 prevalence rate of 21.8% was estimated among the women, with the highest rate of HIV-1 infection (34.1%) among women aged 25 to 29 years.
Stratifying lesions showed a small number of oral hairy leukoplakia to be markers for HIV-1. A high seroprevalence was found in this rural cohort, but there were unexpectedly few oral lesions. The relatively few oral lesions diagnosed may indicate a recent infection with HIV.
研究马拉维农村地区一组孕妇的口腔病变是否与1型人类免疫缺陷病毒（HIV-1）感染状况有关。
638名妇女参与了在马拉维南部农村地区3家产前诊所进行的一项随机前瞻性研究。进行了口腔检查，随后使用HIV-1口腔标本采集装置采集口腔液标本。对标本进行HIV-1抗体检测。
60名参与者中发现61处口腔病变。虽然传统的与HIV-1相关的病变很少见，但良性游走性舌炎意外地很常见（6%）。HIV-1阳性女性的口腔毛状白斑明显比HIV-1阴性女性更常见。估计这些女性中的HIV-1感染率为21.8%，25至29岁女性的HIV-1感染率最高（34.1%）。
对病变进行分层显示，少数口腔毛状白斑是HIV-1的标志物。在这个农村队列中发现了较高的血清阳性率，但口腔病变出人意料地少。诊断出的口腔病变相对较少可能表明最近感染了HIV。
