基因沉默作为一种针对病毒的适应性防御机制。

Gene silencing as an adaptive defence against viruses.

作者信息

Waterhouse P M, Wang M B, Lough T

机构信息

CSIRO Plant Industry, Canberra, ACT, Australia.

出版信息

Nature. 2001 Jun 14;411(6839):834-42. doi: 10.1038/35081168.

DOI:10.1038/35081168

PMID:11459066

Abstract

Gene silencing was perceived initially as an unpredictable and inconvenient side effect of introducing transgenes into plants. It now seems that it is the consequence of accidentally triggering the plant's adaptive defence mechanism against viruses and transposable elements. This recently discovered mechanism, although mechanistically different, has a number of parallels with the immune system of mammals.

摘要

基因沉默最初被视为将转基因引入植物时产生的一种不可预测且不便的副作用。现在看来，它是意外触发植物针对病毒和转座元件的适应性防御机制的结果。这种最近发现的机制，尽管在机制上有所不同，但与哺乳动物的免疫系统有许多相似之处。