Littke A F, Fu G C
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
J Am Chem Soc. 2001 Jul 25;123(29):6989-7000. doi: 10.1021/ja010988c.
In the presence of Cy2NMe, Pd/P(t-Bu)3 serves as an exceptionally mild and versatile catalyst for Heck reactions of aryl chlorides and bromides. A sterically and electronically diverse array of aryl bromides, as well as activated aryl chlorides, couple with a range of mono- and disubstituted olefins at room temperature, furnishing the arylated product with high E/Z stereoselection. The corresponding reactions of a broad spectrum of electron-neutral and electron-rich aryl chlorides proceed at elevated temperature, also with high selectivity. In terms of scope and mildness, Pd/P(t-Bu)3/Cy2NMe represents an advance over previously reported catalysts for these Heck coupling processes.
在Cy2NMe存在的情况下，Pd/P(t-Bu)3作为一种极其温和且通用的催化剂，用于芳基氯和芳基溴的Heck反应。一系列空间和电子性质各异的芳基溴以及活性芳基氯，在室温下能与多种单取代和双取代烯烃发生偶联反应，以高E/Z立体选择性生成芳基化产物。多种电子中性和富电子芳基氯的相应反应在高温下也能进行，且同样具有高选择性。就反应范围和温和性而言，Pd/P(t-Bu)3/Cy2NMe相较于此前报道的用于这些Heck偶联反应的催化剂有了进步。
