Liu S Y, Choi M J, Fu G C
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Chem Commun (Camb). 2001 Dec 7(23):2408-9.
In the presence of new air-stable triarylphosphine 2, palladium-catalyzed Suzuki reactions of a wide array of aryl chlorides can be accomplished in uniformly good yield, including couplings of very sterically demanding and electronically deactivated substrates; activated aryl chlorides can be coupled at room temperature. In terms of scope and mildness, Pd-2 compares well with other catalyst systems that have been described for Suzuki reactions of aryl chlorides, thereby establishing that triarylphosphines should be regarded as fertile ground for future ligand-design efforts for palladium-catalyzed couplings of aryl chlorides.
在新型空气稳定的三芳基膦2存在下，钯催化的多种芳基氯的铃木反应能够以均匀良好的产率完成，包括空间位阻极大和电子钝化底物的偶联反应；活性芳基氯可以在室温下进行偶联。就反应范围和温和性而言，Pd-2与已报道的用于芳基氯铃木反应的其他催化剂体系相比具有优势，从而表明三芳基膦应被视为未来钯催化芳基氯偶联反应配体设计研究的丰富资源。
