新一代抗抑郁药的研究。第1部分：吲哚基环己胺作为强效5-羟色胺再摄取抑制剂
Studies towards the next generation of antidepressants. Part 1: Indolylcyclohexylamines as potent serotonin reuptake inhibitors.
作者信息
Meagher K L, Mewshaw R E, Evrard D A, Zhou P, Smith D L, Scerni R, Spangler T, Abulhawa S, Shi X, Schechter L E, Andree T H
机构信息
Global Chemical Sciences and Neuroscience Departments, Wyeth-Ayerst Research Laboratories, CN 8000, NJ 08543-8000, Princeton, USA.
出版信息
Bioorg Med Chem Lett. 2001 Jul 23;11(14):1885-8. doi: 10.1016/s0960-894x(01)00334-1.
Abstract
A series of indolylcyclohexylamines possessing potent and selective serotonin reuptake inhibition is reported. The most interesting compounds proved to have subnanomolar 5-HT transporter activity, and exhibited moderate 5-HT(1A) affinity.
摘要
据报道，一系列具有强效和选择性5-羟色胺再摄取抑制作用的吲哚基环己胺被发现。最有趣的化合物被证明具有亚纳摩尔级别的5-羟色胺转运体活性，并表现出中等程度的5-羟色胺1A型亲和力。
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