Siddiqui Nadeem, Bawa Sandhya, Ali Ruhi, Afzal Obaid, Akhtar M Jawaid, Azad Bishmillah, Kumar Rajiv
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard University, Hamdard Nagar, New Delhi - 110 062, India.
J Pharm Bioallied Sci. 2011 Apr;3(2):194-212. doi: 10.4103/0975-7406.80765.
Depression is currently the fourth leading cause of disease or disability worldwide. Antidepressant is approved for the treatment of major depression (including paediatric depression), obsessive-compulsive disorder (in both adult and paediatric populations), bulimia nervosa, panic disorder and premenstrual dysphoric disorder. Antidepressant is a psychiatric medication used to alleviate mood disorders, such as major depression and dysthymia and anxiety disorders such as social anxiety disorder. Many drugs produce an antidepressant effect, but restrictions on their use have caused controversy and off-label prescription a risk, despite claims of superior efficacy. Our current understanding of its pathogenesis is limited and existing treatments are inadequate, providing relief to only a subset of people suffering from depression. Reviews of literature suggest that heterocyclic moieties and their derivatives has proven success in treating depression.
抑郁症目前是全球第四大致病或致残原因。抗抑郁药被批准用于治疗重度抑郁症（包括儿童抑郁症）、强迫症（成人和儿童群体）、神经性贪食症、惊恐障碍和经前烦躁障碍。抗抑郁药是一种精神科药物，用于缓解情绪障碍，如重度抑郁症和心境恶劣障碍，以及焦虑症，如社交焦虑障碍。许多药物都有抗抑郁作用，但尽管声称疗效更佳，对其使用的限制却引发了争议，且存在非标签处方的风险。我们目前对其发病机制的理解有限，现有的治疗方法也不够充分，只能使一部分抑郁症患者得到缓解。文献综述表明，杂环部分及其衍生物在治疗抑郁症方面已被证明是成功的。
