Nagai I, Kto Y, Honda T, Nitta S, Hibbs C W
Trans Am Soc Artif Intern Organs. 1975;21:381-7.
Effects of various drugs, such as Isuprel, Neo-synephrine, aminophylline and quinidine, have been evaluated and compared in both control and TAH calves. In the control calves, the cardiac effects of these drugs were overlapped by vascular effects. But in the TAH calves, pure vascular effects have been clearly shown. 1) The peripheral effects of Dibenzyline and Inderal were evaluated in the TAH calves. 2) From these results, it has been concluded that the TAH animal is a useful model for the study of the peripheral vascular response to drugs in awake, unanesthetized subjects.
已在对照小牛和人工心脏置换小牛中评估并比较了多种药物的效果，如异丙肾上腺素、新福林、氨茶碱和奎尼丁。在对照小牛中，这些药物的心脏效应被血管效应所掩盖。但在人工心脏置换小牛中，已清楚显示出单纯的血管效应。1）在人工心脏置换小牛中评估了双苄胺和心得安的外周效应。2）从这些结果得出结论，人工心脏置换动物是研究清醒、未麻醉受试者对外周血管药物反应的有用模型。
