Peripheral effects of cardiovascular drugs during total artificial heart pumping in the awake unanesthetized calf.

Effects of various drugs, such as Isuprel, Neo-synephrine, aminophylline and quinidine, have been evaluated and compared in both control and TAH calves. In the control calves, the cardiac effects of these drugs were overlapped by vascular effects. But in the TAH calves, pure vascular effects have been clearly shown. 1) The peripheral effects of Dibenzyline and Inderal were evaluated in the TAH calves. 2) From these results, it has been concluded that the TAH animal is a useful model for the study of the peripheral vascular response to drugs in awake, unanesthetized subjects.