Gordon S V, Eiglmeier K, Garnier T, Brosch R, Parkhill J, Barrell B, Cole S T, Hewinson R G
Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone, Surrey, UK.
Tuberculosis (Edinb). 2001;81(1-2):157-63. doi: 10.1054/tube.2000.0269.
The imminent completion of the genome sequence of Mycobacterium bovis will reveal the genetic blueprint for this most successful pathogen. Comparative analysis with the genome sequences of M. tuberculosis and M. bovis BCG promises to expose the genetic basis for the phenotypic differences between the tubercle bacilli, offering unparalleled insight into the virulence factors of the M. tuberculosis complex. Initial analysis of the sequence data has already revealed a novel deletion from M. bovis, as well as identifying variation in members of the PPE family of proteins. As the study of bacterial pathogenicity enters the postgenomic phase, the genome sequence of M. bovis promises to serve as a cornerstone of mycobacterial genetics.
牛分枝杆菌基因组序列即将完成，这将揭示这种最成功病原体的遗传蓝图。与结核分枝杆菌和卡介苗牛分枝杆菌的基因组序列进行比较分析，有望揭示结核杆菌表型差异的遗传基础，从而为深入了解结核分枝杆菌复合群的毒力因子提供前所未有的视角。对序列数据的初步分析已经揭示了牛分枝杆菌的一个新缺失，同时也确定了PPE蛋白家族成员的变异。随着细菌致病性研究进入后基因组阶段，牛分枝杆菌的基因组序列有望成为分枝杆菌遗传学的基石。
