过氧化物酶体增殖物激活受体γ：从脂肪生成到肿瘤发生

Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis.

作者信息

Fajas L, Debril M B, Auwerx J

机构信息

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, Université Louis Pasteur, 67404 Illkirch, France.

出版信息

J Mol Endocrinol. 2001 Aug;27(1):1-9. doi: 10.1677/jme.0.0270001.

DOI:10.1677/jme.0.0270001

PMID:11463572

Abstract

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, initially described as molecular targets for synthetic compounds inducing peroxisome proliferation. PPAR-gamma, the best characterized of the PPARs, plays a crucial role in adipogenesis and insulin sensitization. Furthermore, PPAR-gamma has been reported to affect cell proliferation/differentiation pathways in various malignancies. We discuss in the present review recent advances in the understanding of the function of PPAR-gamma in both cell proliferation and adipocyte differentiation.

摘要

过氧化物酶体增殖物激活受体（PPARs）是核激素受体，最初被描述为诱导过氧化物酶体增殖的合成化合物的分子靶点。PPAR-γ是PPARs中研究最深入的一种，在脂肪生成和胰岛素敏感性方面发挥着关键作用。此外，据报道PPAR-γ会影响各种恶性肿瘤中的细胞增殖/分化途径。在本综述中，我们讨论了在理解PPAR-γ在细胞增殖和脂肪细胞分化中的功能方面的最新进展。