Garg B D, Kovacs K, Tuchweber B, Khandekar J D
Acta Anat (Basel). 1975;91(2):161-74. doi: 10.1159/000144380.
PCN, a microsomal enzyme inducer, given orally (10 mg in 1 ml water twice daily for 5 days), increased liver weight and mitotic activity in intact as well as in partially hepatectomized rats. Electron microscopy revealed SER proliferation in the hepatocytes of animals treated with PCN alone. Accumulation of SER membranes was also evident in the liver cell cytoplasm of untreated, partially hepatectomized rats; it was however, more pronounced in the hepatocytes of partially hepatectomized animals given PCN. These results indicate that the steriod has a marked effect on the regeneration rat liver.
苯巴比妥钠（PCN）是一种微粒体酶诱导剂，口服给药（10毫克溶于1毫升水中，每日两次，共5天）可使完整大鼠和部分肝切除大鼠的肝脏重量和有丝分裂活性增加。电子显微镜检查显示，单独接受PCN治疗的动物肝细胞中滑面内质网（SER）增生。在未治疗的部分肝切除大鼠的肝细胞胞质中也明显可见SER膜的积累；然而，在接受PCN治疗的部分肝切除动物的肝细胞中更为明显。这些结果表明，该甾体对大鼠肝脏再生有显著影响。
