放线菌酮对孕烯醇酮-16α-腈（PCN）诱导的大鼠肝脏超微结构变化的影响。
Effect of cycloheximide on pregnenolone-16alpha-carbonitrile (PCN)-induced ultrastructural changes in the rat liver.
作者信息
Garg B D, Tuchweber B, Kovacs K
出版信息
Pathol Biol (Paris). 1975 Sep;23(7):511-6.
PMID:1101152
Abstract
Cycloheximide (10 mg/100 g body weight i.v. twice), an inhibitor of protein synthesis, caused smooth endoplasmic reticulum (SER) accumulation in the hepatocytes of female rats. Pregnenolone-16alpha-carbonitrile (PCN), given p.o., had a similar effect. When cycloheximide was administered to PCN-treated rats, SER proliferation as well as myelin figure formation were noted.
摘要
蛋白质合成抑制剂环己酰亚胺（静脉注射，10毫克/100克体重，分两次给药）导致雌性大鼠肝细胞中滑面内质网（SER）蓄积。口服孕烯醇酮-16α-腈（PCN）也有类似作用。当对经PCN处理的大鼠给予环己酰亚胺时，观察到SER增生以及髓鞘样结构形成。
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