Willén R, Nathanson A, Moberger G, Anneroth G
Acta Otolaryngol. 1975 Jan-Feb;79(1-2):146-54. doi: 10.3109/00016487509124667.
A histological classification and grading of malignancy has been performed on the initial biopsies from 124 patients with squamous-cell carcinoma of the gingiva treated during the period 1958-69 at the Karolinska hospital. Six different morphological parameters were evaluated with respect to the tumour cell population and the tumour-host relationship estimated in terms of a four-point scale. This permitted grading with total points ranging from 6-24. A strong correlation was found between the degree of histological malignancy and the fatal outcome of the disease. Thus a tumour with a point value of 16 almost always led to the death of the patient while the best results were achieved with surgery alone in the group of small cancers (T1 + T2) with low total malignancy points.
对1958年至1969年期间在卡罗林斯卡医院接受治疗的124例牙龈鳞状细胞癌患者的初始活检标本进行了恶性肿瘤的组织学分类和分级。针对肿瘤细胞群体评估了六个不同的形态学参数，并根据四点量表评估了肿瘤与宿主的关系。这使得总积分范围为6至24分的分级成为可能。发现组织学恶性程度与疾病的致命结局之间存在密切相关性。因此，积分值为16的肿瘤几乎总会导致患者死亡，而在总恶性积分较低的小癌症（T1 + T2）组中，单纯手术治疗取得了最佳效果。
