Department for Oral and Craniomaxillofacial Plastic Surgery, University of Cologne, Kerpener Straße 62, 50931, Cologne, Germany.
Center for Integrated Oncology Cologne-Bonn, Cologne, Germany.
Clin Oral Investig. 2019 Oct;23(10):3759-3765. doi: 10.1007/s00784-019-02804-4. Epub 2019 Jan 23.
Tumor invasion into blood and/or lymphatic vessels, perineural invasion, and histopathological grading are evaluated to assess the biological aggressiveness of oral squamous cell carcinoma (OSCC). We aim to assess the prognostic impact of a novel scoring system, based upon the aforementioned histological parameters.
Retrospective chart review of 334 patients with treatment-naive squamous cell carcinoma of the oral cavity. Statistical analysis was performed using univariate and multivariate analysis. Histological grade G1 or G2 were assigned 0 points and G3 or G4 1 point. Invasion of the lymphatic vessels, blood vessels, or perineural space was given 1 point. Zero points were given, when invasion was not detectable. The final score was conducted through addition of each parameter. Therefore, our scoring system ranged between 0 and 4 points.
T-classification (p < 0.001), N-classification (p < 0.001), UICC stage (p < 0.001), extracapsular spread (p < 0.001), locoregional recurrence (p < 0.001), and overall survival (p < 0.001) were significantly associated with the OSCC-Histoscore. In multivariate analysis, T-classification (p = 0.001), N-classification (p = 0.039), resection margins (p = 0.038), and OSCC-Histoscore (p < 0.001) were independent prognostic markers for overall survival rate.
Our presented OSCC-Histoscore serves as a strong independent prognostic parameter for 5-year overall survival (OS) and predicts OS better than T-classification, N-classification, and resection margins.
Our presented histoscore improves prediction of the overall survival of patients with OSCC.
肿瘤侵犯血管和/或淋巴管、神经周围侵犯以及组织病理学分级用于评估口腔鳞状细胞癌（OSCC）的生物学侵袭性。我们旨在评估一种新的评分系统的预后影响，该评分系统基于上述组织学参数。
对 334 例未经治疗的口腔鳞状细胞癌患者进行回顾性图表审查。使用单变量和多变量分析进行统计分析。组织学分级 G1 或 G2 赋值 0 分，G3 或 G4 赋值 1 分。淋巴管、血管或神经周围空间的侵犯给予 1 分。当无法检测到侵犯时，给予 0 分。通过添加每个参数来进行最终评分。因此，我们的评分系统范围在 0 到 4 分之间。
T 分类（p<0.001）、N 分类（p<0.001）、UICC 分期（p<0.001）、包膜外扩散（p<0.001）、局部区域复发（p<0.001）和总生存率（p<0.001）与 OSCC-Histoscore 显著相关。多变量分析显示，T 分类（p=0.001）、N 分类（p=0.039）、切缘（p=0.038）和 OSCC-Histoscore（p<0.001）是总生存率的独立预后标志物。
我们提出的 OSCC-Histoscore 是 5 年总生存率（OS）的强有力独立预后参数，预测 OS 优于 T 分类、N 分类和切缘。
我们提出的组织学评分提高了对 OSCC 患者总生存率的预测。
