Svanberg L, Linell F, Pandolfi M, Astedt B
Acta Pathol Microbiol Scand A. 1975 Mar;83(2):193-8. doi: 10.1111/j.1699-0463.1975.tb01374.x.
Ovarian tumours obtained at laparotomy were histochemically examined for their local fibrinolytic activity, and simultaneous fibrin/fibrinogen degradation products (FDP) were determined in the serum. The fibrinolytic activity was confined mainly to vessels of both malignant and benign tumours. A very close correlation was demonstrated between the fibrinolytic activity and the vascularity of the sections. FDP were found in the serum in 13 of 14 patients with malignant tumours, but in none with benign tumours. The difference in occurrence of FDP in patients with malignant and benign tumours might be due to the invasive growth of the former with the entrance of thromboplastic substances, fibrinolytic activators or locally formed FDP into the bloodstream.
对剖腹手术时获取的卵巢肿瘤进行组织化学检查，以检测其局部纤维蛋白溶解活性，并同时测定血清中的纤维蛋白/纤维蛋白原降解产物（FDP）。纤维蛋白溶解活性主要局限于恶性和良性肿瘤的血管。切片的纤维蛋白溶解活性与血管形成之间显示出非常密切的相关性。14例恶性肿瘤患者中有13例血清中发现有FDP，但良性肿瘤患者均未发现。恶性和良性肿瘤患者FDP出现情况的差异可能是由于前者的浸润性生长，导致促凝物质、纤维蛋白溶解激活剂或局部形成的FDP进入血流。
