Astedt B, Svanberg L, Nilsson I M
Br Med J. 1971 Nov 20;4(5785):458-9. doi: 10.1136/bmj.4.5785.458.
Fibrin degradation products (F.D.P.) were determined in the serum of 163 women in whom ovarian tumours had been suspected on palpation at gynaecological examination and who were afterwards examined by laparoscopy or subjected to laparotomy. F.D.P. were found in the serum (0.5-30 mg/100 ml) of 23 (72%) out of 32 patients with malignant tumours. Of 131 patients with benign findings F.D.P. (traces to 2 mg/100 ml) were found in six (4.5%), and in most of these the occurrence of F.D.P. could be explained on other clinical grounds. The findings suggest that the examination of F.D.P. in suspected malignant ovarian tumour may be of diagnostic value.Determination of F.D.P. in malignant ascitic fluid showed very high values, ranging between 40 and 350 mg/ 100 ml. This argues for the occurrence of F.D.P. in the blood being due to an extravascular breakdown of fibrin caused by tumour cells, but they may also be due to thromboplastic and fibrinolytic agents from the tumour entering the blood stream.
对163名女性的血清进行了纤维蛋白降解产物（F.D.P.）测定。这些女性在妇科检查时经触诊怀疑患有卵巢肿瘤，随后接受了腹腔镜检查或剖腹手术。在32例恶性肿瘤患者中，有23例（72%）血清中检测到F.D.P.（0.5 - 30毫克/100毫升）。在131例检查结果为良性的患者中，有6例（4.5%）检测到F.D.P.（微量至2毫克/100毫升），而且在大多数情况下，F.D.P.的出现可以用其他临床原因来解释。这些结果表明，对疑似恶性卵巢肿瘤患者进行F.D.P.检查可能具有诊断价值。对恶性腹水进行F.D.P.测定显示，其值非常高，范围在40至350毫克/100毫升之间。这表明血液中F.D.P.的出现是由于肿瘤细胞引起的血管外纤维蛋白分解，但也可能是由于肿瘤中的促凝和纤溶因子进入了血流。
