Connor D T, von Strandtmann M
J Med Chem. 1979 Sep;22(9):1055-9. doi: 10.1021/jm00195a009.
Alcohol, ketone, aldehyde, and oxime analogues of ambruticin (1) were prepared. The analogues were tested against Histoplasma capsulatum, Microsporum fulvum, Candida albicans, and Streptococcus pyogenes. Structure-activity relationships are described. Increasing the bulk of substituent at C1 and C5 reduces antifungal activity.
制备了氨布律汀（1）的醇、酮、醛和肟类似物。对这些类似物针对荚膜组织胞浆菌、黄小孢子菌、白色念珠菌和化脓性链球菌进行了测试。描述了构效关系。增大C1和C5位取代基的体积会降低抗真菌活性。
