Hanakawa T, Ikeda A, Sadato N, Okada T, Fukuyama H, Nagamine T, Honda M, Sawamoto N, Yazawa S, Kunieda T, Ohara S, Taki W, Hashimoto N, Yonekura Y, Konishi J, Shibasaki H
Department of Brain Pathophysiology, Human Brain Research Center, Kyoto University Graduate School of Medicine, Japan.
Exp Brain Res. 2001 Jun;138(4):403-9. doi: 10.1007/s002210100727.
Two functional brain-mapping techniques, functional magnetic resonance imaging (fMRI) and cortical stimulation by chronically implanted subdural electrodes, were used in combination for presurgical evaluation of three patients with intractable, partial motor seizures. Brain mapping was focused on characterizing motor-related areas in the medial frontal cortex, where all patients had organic lesions. Behavioral tasks for fMRI involved simple finger and foot movements in all patients and mental calculations in one of them. These tasks allowed us to discriminate several medial frontal motor areas: the presupplementary motor areas (pre-SMA), the somatotopically organized SMA proper, and the foot representation of the primary motor cortex. All patients subsequently underwent cortical stimulation through subdural electrodes placed onto the medial hemispheric wall. In each patient, the cortical stimulation map was mostly consistent with that patient's brain map by fMRI. By integrating different lines of information, the combined fMRI and cortical stimulation map will contribute not only to safe and effective surgery but also to further understanding of human functional neuroanatomy.
两种功能性脑图谱技术，即功能磁共振成像（fMRI）和通过长期植入硬膜下电极进行皮质刺激，被联合用于对三名患有顽固性部分运动性癫痫的患者进行术前评估。脑图谱聚焦于内侧额叶皮质中与运动相关区域的特征描述，所有患者在此区域均有器质性病变。fMRI的行为任务在所有患者中包括简单的手指和足部运动，其中一名患者还包括心算。这些任务使我们能够区分几个内侧额叶运动区域：辅助运动前区（pre-SMA）、按躯体定位组织的真正辅助运动区（SMA proper）以及初级运动皮质的足部代表区。所有患者随后都通过放置在内侧半球壁上的硬膜下电极接受了皮质刺激。在每位患者中，皮质刺激图谱与该患者通过fMRI获得的脑图谱基本一致。通过整合不同的信息线索，联合的fMRI和皮质刺激图谱不仅将有助于安全有效的手术，还将有助于进一步理解人类功能性神经解剖学。
