Bierrenbach A L, Cunha S S, Barreto M L, Pereira S M, Rodrigues L C
London School of Hygiene and Tropical Medicine, London University, UK.
Int J Tuberc Lung Dis. 2001 Jul;5(7):656-63.
City of Manaus, Amazonas, Brazil.
To explore the relationship between positivity to tuberculin and other environmental mycobacteria sensitins, according to a range of criteria and presence of BCG scar.
Dual skin testing with tuberculin and four mycobacterial sensitins, and BCG scar recording of 1070 schoolchildren aged 7-14. Four criteria for positivity were used: simple and dominant, with 5 and 10 mm cut-off points.
The standardised prevalence of reactions > or = 5 mm for BCG scar negative children was 58.3% for Mycobacterium avium, 54.2% for M. scrofulaceum, 26.8% for M. fortuitum, 17.9% for M. tuberculosis and 7.6% for M. kansasii. Correlations between tuberculin and each sensitin, for BCG scar negative children, were 0.47 for M. avium, 0.53 for M. scrofulaceum, 0.60 for M. kansasii and 0.22 for M. fortuitum (all with P < 0.01). BCG effect was particularly significant for tuberculin (odds ratio = 3.44 for reactions > or = 5 mm, P < 0.001) and influenced the balance between dominant/non-dominant reactions for all sensitins.
The correlation between tuberculin and each sensitin confirmed the separation of the rapidly (M. fortuitum) and slowly growing mycobacteria (M. tuberculosis, M. avium, M. scrofulaceum and M. kansasii). The influence of BCG on tuberculin reactions was more marked than on other mycobacterial sensitins.
巴西亚马孙州玛瑙斯市。
根据一系列标准以及卡介苗疤痕的存在情况，探究结核菌素阳性与其他环境分枝杆菌致敏之间的关系。
对1070名7 - 14岁学童进行结核菌素和四种分枝杆菌致敏原的双重皮肤试验，并记录卡介苗疤痕情况。使用了四种阳性标准：简单标准和优势标准，截断值分别为5毫米和10毫米。
卡介苗疤痕阴性儿童中，反应≥5毫米的标准化患病率，鸟分枝杆菌为58.3%，瘰疬分枝杆菌为54.2%，偶然分枝杆菌为26.8%，结核分枝杆菌为17.9%，堪萨斯分枝杆菌为7.6%。对于卡介苗疤痕阴性儿童，结核菌素与各致敏原之间的相关性，鸟分枝杆菌为0.47，瘰疬分枝杆菌为0.53，堪萨斯分枝杆菌为0.60，偶然分枝杆菌为0.22（均P < 0.01）。卡介苗对结核菌素的影响尤为显著（反应≥5毫米的优势比 = 3.44，P < 0.001），并影响了所有致敏原优势/非优势反应之间的平衡。
结核菌素与各致敏原之间的相关性证实了快速生长（偶然分枝杆菌）和缓慢生长分枝杆菌（结核分枝杆菌、鸟分枝杆菌、瘰疬分枝杆菌和堪萨斯分枝杆菌）的区分。卡介苗对结核菌素反应的影响比对其他分枝杆菌致敏原的影响更为明显。
