Osman A A, Hakim J G, Lüneborg-Nielsen M, Bentzon M W, Magnusson M, Ageel A M, Zakaria E, Saleem A, Bakdash I
King Fahd Central Hospital, Jizan, Kingdom of Saudi Arabia.
Tuber Lung Dis. 1994 Feb;75(1):38-43. doi: 10.1016/0962-8479(94)90100-7.
Jizan region, Saudi Arabia.
To test methodology for studies of tuberculin sensitivity and effectiveness of BCG vaccination programme.
School children (n = 315) aged 6-12 years simultaneously tested intradermally with PPD tuberculin RT23, 2TU and 0.1 microgram Mycobacterium avium or M. scrofulaceum sensitin. Presence of BCG scar as evidence of previous BCG vaccination. Cervical lymph nodes palpated.
BCG coverage was 75%. The prevalences of positive reactions (induration > or = 6 mm) were higher among children with than without scar. Prevalences of positive reactions to PPD and M. scrofulaceum sensitin were higher among girls than boys. In children with scar, the mean size of positive reactions to PPD was larger among girls than boys, and the prevalence of positive reactions was smaller in this group among children with than without palpable cervical lymph nodes. The sizes of reactions both to M. avium and to M. scrofulaceum sensitin were correlated to the size of the tuberculin reactions. Previous admission to hospital was reported less often by children with than without scar.
The technique applied and training of staff was satisfactory. In further studies, however, we will apply three simultaneous tests to each person.
沙特阿拉伯吉赞地区。
测试结核菌素敏感性研究方法及卡介苗接种计划的有效性。
对315名6至12岁的学童同时进行皮内注射，分别注射PPD结核菌素RT23、2TU以及0.1微克鸟分枝杆菌或瘰疬分枝杆菌变应原。以卡介苗疤痕作为既往接种卡介苗的证据。触诊颈部淋巴结。
卡介苗接种覆盖率为75%。有疤痕的儿童中阳性反应（硬结≥6毫米）的患病率高于无疤痕的儿童。对PPD和瘰疬分枝杆菌变应原呈阳性反应的患病率女孩高于男孩。在有疤痕的儿童中，女孩对PPD阳性反应的平均大小大于男孩，且在该组中有可触及颈部淋巴结的儿童中阳性反应的患病率低于无可触及颈部淋巴结的儿童。对鸟分枝杆菌和瘰疬分枝杆菌变应原的反应大小与结核菌素反应大小相关。有疤痕的儿童报告既往住院的情况少于无疤痕的儿童。
所应用的技术及工作人员的培训情况令人满意。然而，在进一步的研究中，我们将对每个人同时进行三项测试。
