Smalley M J, Dale T C
CRC Centre for Cell and Molecular Biology, Institute of Cancer Research, London, United Kingdom.
J Mammary Gland Biol Neoplasia. 2001 Jan;6(1):37-52. doi: 10.1023/a:1009564431268.
Wnt expression patterns during mammary development support a role for Wnts in breast development and in mammary epithelial responses to systemic hormones. The deregulation of Wnt signaling also plays a role in breast cancer. Activation of the Wnt signaling pathway is a major feature of several human neoplasias and appears to lead to the cytosolic stabilization of a transcriptional co-factor, beta-catenin. This co-activator can then regulate transcription from a number of target genes including the cellular oncogenes cyclin D1 and c-myc. This review will summarize the current state of knowledge of Wnt signal transduction in a range of model systems and will then address the role of Wnts and Wnt signaling in mammary development and cancer.
在乳腺发育过程中，Wnt的表达模式表明Wnt在乳腺发育以及乳腺上皮对全身性激素的反应中发挥作用。Wnt信号传导失调在乳腺癌中也起作用。Wnt信号通路的激活是几种人类肿瘤形成的主要特征，并且似乎导致转录辅因子β-连环蛋白在细胞质中的稳定。然后这种共激活因子可以调节许多靶基因的转录，包括细胞癌基因细胞周期蛋白D1和c-myc。本综述将总结一系列模型系统中Wnt信号转导的当前知识状态，然后探讨Wnt和Wnt信号传导在乳腺发育和癌症中的作用。
