Izbéki F, Wittmann T, Csáti S, Jeszenszky E, Lonovics J
University of Szeged, Faculty of Medicine, 1st Department of Internal Medicine, Szeged, Hungary.
Alcohol Alcohol. 2001 Jul-Aug;36(4):304-8. doi: 10.1093/alcalc/36.4.304.
The effects of acute and chronic administration of a large dose of alcohol on gastric emptying and small bowel transit were studied in rats. The development of tolerance to the acute effect of alcohol on gastrointestinal motility during chronic alcohol administration was also investigated. Gastric emptying and small intestinal transit were assessed by the Phenol Red recovery method. Acutely, ethanol was given in a dose of 2.5 g/kg body wt by gavage 30 min before the test meal. Chronically, ethanol was administered by two different methods: (1) a dose of 2.5 g/kg body wt was administered by gavage daily for 10 days; (2) animals received 15% ethanol in their drinking water for 30 days. A single large dose of alcohol inhibited gastric emptying and small bowel transit. Treatment with a large dose of alcohol for 10 days did not change the gastric emptying significantly, but inhibited the small intestinal transit. Alcohol consumption in drinking water for 30 days accelerated gastric emptying and small bowel transit. Tolerance to the acute inhibitory effect of a single large dose of alcohol on gastrointestinal motility did not develop during chronic alcohol treatment.
研究了大剂量酒精急性和慢性给药对大鼠胃排空和小肠转运的影响。还研究了慢性酒精给药期间对酒精对胃肠动力急性作用的耐受性发展情况。采用酚红回收法评估胃排空和小肠转运。急性给药时，在试验餐30分钟前通过灌胃给予2.5 g/kg体重的乙醇。慢性给药时，采用两种不同方法给予乙醇：(1) 每天通过灌胃给予2.5 g/kg体重，共10天；(2) 动物在饮水中给予15%乙醇，持续30天。单次大剂量酒精抑制胃排空和小肠转运。大剂量酒精治疗10天未显著改变胃排空，但抑制小肠转运。饮水中含酒精30天加速胃排空和小肠转运。慢性酒精治疗期间未产生对单次大剂量酒精对胃肠动力急性抑制作用的耐受性。
