Edelbroek M A, Horowitz M, Wishart J M, Akkermans L M
Department of Surgery, University Hospital Utrecht, The Netherlands.
J Nucl Med. 1993 Apr;34(4):582-8.
The effects of erythromycin on gastric emptying and intragastric distribution of a mixed solid/liquid meal, alcohol absorption and small intestinal transit were examined in eight male volunteers. Each subject received, in double-blind randomized order, either erythromycin as the lactobionate (3 mg.kg-1 i.v. over 20 min) or saline immediately before the consumption of a radioisotopically labeled test meal, which consisted of 330 g minced beef and 400 ml of orange juice containing ethanol (0.5 g.kg-1 body weight) and 10 g lactulose. Erythromycin increased the rate of total stomach emptying and proximal stomach emptying of both the solid and liquid components of the meal (p < 0.001), but slowed small intestinal transit (p < 0.01). Peak blood alcohol concentrations (p < 0.01) were higher after erythromycin, with a mean increase of 40%. There was a significant inverse relationship between peak blood alcohol concentrations and the 50% emptying time for the liquid component of the meal after saline (r = -0.70, p < 0.05), but not after erythromycin (r = -0.57, p < 0.1). The total area under the venous blood alcohol concentration time curve (i.e., total absorption) was greater (p < 0.01) after erythromycin. These results suggest that: faster emptying from the proximal stomach contributes to more rapid gastric emptying induced by erythromycin, erythromycin retards small intestinal transit and that erythromycin increases the total amount of alcohol absorbed as well as the rate of alcohol absorption. These latter effects are likely to reflect more rapid delivery of alcohol to the small intestine and reduced metabolism of alcohol by the gastric mucosa.
在八名男性志愿者中研究了红霉素对混合固体/液体餐的胃排空、胃内分布、酒精吸收及小肠转运的影响。每位受试者按照双盲随机顺序，在食用放射性同位素标记的试验餐之前，静脉注射乳糖酸红霉素（3mg·kg-1，20分钟内注射完毕）或生理盐水，试验餐包含330g碎牛肉、400ml含乙醇（0.5g·kg-1体重）和10g乳果糖的橙汁。红霉素增加了餐食固体和液体成分的总胃排空率及近端胃排空率（p<0.001），但减缓了小肠转运（p<0.01）。红霉素注射后血中酒精浓度峰值更高（p<0.01），平均升高40%。生理盐水注射后，血中酒精浓度峰值与餐食液体成分50%排空时间之间存在显著负相关（r=-0.70，p<0.05），但红霉素注射后无此相关性（r=-0.57，p<0.1）。红霉素注射后静脉血酒精浓度时间曲线下的总面积（即总吸收量）更大（p<0.01）。这些结果表明：近端胃更快排空有助于红霉素诱导的更快速胃排空，红霉素延缓小肠转运，且红霉素增加了酒精吸收总量及酒精吸收速率。后一种效应可能反映了酒精更快地输送至小肠以及胃黏膜对酒精代谢的减少。
