Mishier J M, Jackson C A, Nicora R W, Julien R M
Am J Hosp Pharm. 1975 May;32(5):489-91.
An in vivo study was conducted to determine if there were differences in local anesthetic potency between two commercial brands of lidocaine. The two preparations were evaluated in terms of onset of action, peak effects and duration of action using a double-blink technique. Both products were tested at concentrations of 0.25%, 0.50% and 1%. Each were evaluated for conduction (in rats), topical (in rabbits) and in filtration (in guinea pigs) anesthesia. No clinically significant differences between the two commercial preparations were found.
进行了一项体内研究，以确定两种市售品牌利多卡因的局部麻醉效力是否存在差异。使用双眨眼技术，根据起效时间、峰值效应和作用持续时间对这两种制剂进行评估。两种产品均在0.25%、0.50%和1%的浓度下进行测试。每种产品都针对传导（在大鼠中）、局部（在兔子中）和浸润（在豚鼠中）麻醉进行了评估。未发现两种市售制剂之间存在临床显著差异。
