Varrato J, Siderowf A, Damiano P, Gregory S, Feinberg D, McCluskey L
Department of Neurology, University of Pennsylvania, Philadelphia, USA.
Neurology. 2001 Jul 24;57(2):357-9. doi: 10.1212/wnl.57.2.357.
The detection of respiratory muscle weakness in ALS is necessary to plan initiation of noninvasive positive pressure ventilation and begin discussion of advanced directives. The authors measured the erect seated and supine forced vital capacity (FVC) in 38 patients with ALS and 15 controls. The supine FVC is significantly lower and the erect--supine FVC difference is significantly greater in patients with complaints of dyspnea, orthopnea, and daytime fatigue.
检测肌萎缩侧索硬化症（ALS）患者的呼吸肌无力情况对于规划启动无创正压通气及开始讨论预立医疗指示很有必要。作者测量了38例ALS患者和15名对照者的直立坐位及仰卧位用力肺活量（FVC）。有呼吸困难、端坐呼吸及日间疲劳主诉的患者，其仰卧位FVC显著更低，直立位与仰卧位FVC差值显著更大。
