Department of Neurology, University of California, Irvine, CA, USA,
Curr Treat Options Neurol. 2014 Feb;16(2):270. doi: 10.1007/s11940-013-0270-5.
Amyotrophic lateral sclerosis (ALS) is an uncommon and almost invariably fatal neurodegenerative disease. There is no known cure for ALS, and only one disease-modifying therapy is currently approved. In the absence of robust pharmacologic treatment options, the value of nutritional and respiratory support in the management of the disease should not be underestimated. The primary causes of morbidity and mortality in ALS are complications from dysphagia, leading to malnutrition and respiratory insufficiency, and these require focused therapeutic attention. This article reviews the current evidence for nutritional and respiratory support in the management of ALS patients.
肌萎缩侧索硬化症（ALS）是一种罕见且几乎总是致命的神经退行性疾病。目前尚无针对 ALS 的已知治愈方法，仅有一种疾病修正疗法获得批准。在缺乏强有力的药物治疗选择的情况下，营养和呼吸支持在疾病管理中的价值不应被低估。ALS 患者的发病率和死亡率的主要原因是吞咽困难引起的并发症，导致营养不良和呼吸功能不全，这需要给予针对性的治疗关注。本文综述了目前在 ALS 患者管理中营养和呼吸支持的证据。
