McGrath J W, George K, Svilar G, Ihler E, Mafigiri D, Kabugo M, Mugisha E
Department of Anthropology, Case Western Reserve University, Cleveland, Ohio 44106-7125, USA.
J Acquir Immune Defic Syndr. 2001 Aug 1;27(4):381-8. doi: 10.1097/00126334-200108010-00009.
In preparation for HIV vaccine trials, knowledge about vaccines, willingness to participate in a vaccine study, and motivations for participation must be assessed. The Preparation for AIDS Vaccine Evaluation study assessed knowledge about vaccines and vaccine trials and willingness to participate in a hypothetical trial in 1,182 Ugandan military men (aged 18-30 years). Participants received education about vaccine trials and were interviewed during 24 months of follow-up observation. Its key findings are that: 1) throughout follow-up, most participants expressed willingness to participate in a hypothetical HIV vaccine trial; 2) participants are familiar with vaccines but do not clearly distinguish the use of vaccines for prevention or curing; 3) the most common reason given for being interested in participating in a vaccine trial was to be protected from HIV/AIDS; 4) trials' procedures (e.g., placebos, randomization, and blinding) were unfamiliar; and 5) knowledge about trials' procedures increased incrementally over follow-up, but at different rates for different concepts. These data demonstrate that potential vaccine trials' participants may benefit from vaccine trial education if adequate time is allowed to ensure that participants are able to master the complex information required for trial participation.
在筹备艾滋病疫苗试验时，必须评估对疫苗的了解、参与疫苗研究的意愿以及参与的动机。“艾滋病疫苗评估准备研究”评估了1182名乌干达军人（年龄在18至30岁之间）对疫苗和疫苗试验的了解以及参与一项假设试验的意愿。参与者接受了关于疫苗试验的教育，并在24个月的随访观察期间接受了访谈。其主要发现如下：1）在整个随访过程中，大多数参与者表示愿意参与一项假设的艾滋病疫苗试验；2）参与者对疫苗有所了解，但没有明确区分疫苗用于预防还是治疗；3）参与疫苗试验最常见的原因是预防感染艾滋病病毒/艾滋病；4）对试验程序（如安慰剂、随机分组和盲法）不熟悉；5）对试验程序的了解在随访过程中逐渐增加，但不同概念的增长速度不同。这些数据表明，如果有足够的时间确保参与者能够掌握参与试验所需的复杂信息，潜在的疫苗试验参与者可能会从疫苗试验教育中受益。
