Molinié V
Service d'Anatomie Pathologique, Hôpital Foch, 40, rue Worth, 92151 Suresnes Cedex.
Ann Pathol. 2001 Jun;21(3):245-54.
Prostatic intraepithelial neoplasia (PIN) is the histologic lesion most strongly associated with prostate cancer and has been postulated to be a pre-malignant lesion. However, much of the natural history of PIN remains unknown. A more fundamental understanding of the relationship between PIN and invasive tumors at the molecular level is critically needed and represents an important future challenge for investigators. The importance of their recognition are based on the correlation between their presence and the existence of prostatic adenocarcinomas. It seemed significant to us to point out the criteria of the diagnosis and the action to be taken in front of the discovery of such lesions on biopsies in prostate sufferers.
前列腺上皮内瘤变（PIN）是与前列腺癌关联最为密切的组织学病变，被认为是一种癌前病变。然而，PIN的许多自然史仍不为人知。亟需在分子水平上更深入地了解PIN与浸润性肿瘤之间的关系，这是研究人员未来面临的一项重要挑战。对它们进行识别的重要性基于其存在与前列腺腺癌存在之间的相关性。对我们来说，指出诊断标准以及在前列腺患者活检中发现此类病变时应采取的措施似乎很重要。
