Nicoli S, Colombo P
Dipartimento Farmaceutico, Parcó Area delle Scienze 27/A, Università di Parma, Parma, Italia.
Ann Pharm Fr. 2001 Jul;59(4):227-31.
The notion of controlled release has been known since the 1930s, but was not significantly developed until the 1970s. At that time, Alza introduced the concept of a "therapeutic system" and proposed new pharmaceutic formulations. Over time, the idea became one of controlled drug delivery and today concerns not only one rate of release but also the site of release of the active substance. We present here definitions, fundamentals and advantages and disadvantages of currently marketed systems and provide examples illustrating oral, transdermal and respiratory delivery systems. Current research is also examined.
控释的概念自20世纪30年代就已为人所知，但直到20世纪70年代才得到显著发展。当时，阿尔扎公司引入了“治疗系统”的概念，并提出了新的药物制剂。随着时间的推移，这一理念演变成了药物控释，如今不仅涉及活性物质的释放速率，还涉及释放部位。我们在此介绍目前市售系统的定义、基本原理、优缺点，并提供说明口服、透皮和呼吸给药系统的示例。同时也对当前的研究进行了探讨。
