Germaud P, Renaudin K, Danner I, Morin O, De Lajartre A Y
Service de Pneumologie, CHRU Nantes, Hôpital G. et R. Laënnec, 44093 Nantes Cedex.
Rev Mal Respir. 2001 Jun;18(3):257-66.
Bronchopulmonary aspergillosis are in the news. Invasive pulmonary aspergillosis raise early diagnostic problems and prevention problems in immunocompromised patients. These infections are no unusual in chronic obstructive pulmonary disease. The diagnosis between aspergilloma and chronic necrotizing pulmonary aspergillosis can be difficult. In allergic bronchopulmonary aspergillosis, epidemiology and therapy are questionable. Real progress has been made due to thoracic computed tomographic scan and mycological methods. Better use of amphotericin B, of amphotericin B lipid formulations and of azole antifungal agents, combined with surgical resection if necessary should improve aspergillosis prognosis.
支气管肺曲霉病成为新闻热点。侵袭性肺曲霉病在免疫功能低下患者中引发了早期诊断问题和预防问题。这些感染在慢性阻塞性肺疾病中并不罕见。曲菌球与慢性坏死性肺曲霉病之间的诊断可能很困难。在变应性支气管肺曲霉病中,流行病学和治疗方法存在疑问。由于胸部计算机断层扫描和真菌学方法,已经取得了实际进展。更好地使用两性霉素B、两性霉素B脂质制剂和唑类抗真菌剂,并在必要时结合手术切除,应能改善曲霉病的预后。