接受铊-201和锝-99M甲氧基异丁基异腈的患者的尿排泄和外照射剂量。

Urinary excretion and external radiation dose from patients administered thallium-201 and technetium-99M methoxy isobutyl isonitrile.

作者信息

Sattari A, Dadashzadeh S, Nasiroghli G

机构信息

Cyclotron Department, Nuclear Research Centre for Agriculture and Medicine (NRCAM), PO Box 31585-4395, Karaj, Iran.

出版信息

Radiat Prot Dosimetry. 2001;95(1):59-61. doi: 10.1093/oxfordjournals.rpd.a006525.

DOI:10.1093/oxfordjournals.rpd.a006525

PMID:11468808

Abstract

In this study, the dose rates at various distances of 5, 10, 50 and 100 cm from 70 patients, who were administered diagnostic amounts of 201Tl-chloride and 99Tcm-MIBI, was measured using an ionisation chamber. The maximum values of external dose rates of 201Tl and 99Tcm-MIBI were 11.2 microSv.h-1 +/- 2.3 and 43.1 microSv.h-1 +/- 11.9 respectively at 5 cm from the patients. Significant exposure from patients after injection of 99Tcm-MIBI was limited on the day of administration. Departure dose rates of 201Tl fell gradually so by 3 days after administration were significant. All excreted urine was also collected from 16 patients for the 24 days after administration. The urinary excretion rate of 201Tl was slow; about 2% of the activity within 24 h after injection. The urinary excretion of 99Tcm-MIBI was rapid, and a large amount of activity was excreted in a few hours after injection; 22% within 20 h after injection.

摘要

在本研究中，使用电离室测量了70例接受诊断剂量的氯化铊-201和锝-99m甲氧基异丁基异腈（99Tcm-MIBI）的患者在距离其5、10、50和100 cm不同距离处的剂量率。氯化铊-201和锝-99m甲氧基异丁基异腈的外部剂量率最大值分别为：在距离患者5 cm处，氯化铊-201为11.2微希沃特·小时⁻¹±2.3，锝-99m甲氧基异丁基异腈为43.1微希沃特·小时⁻¹±11.9。注射锝-99m甲氧基异丁基异腈后患者的显著暴露在给药当天受限。氯化铊-201的出院剂量率逐渐下降，因此给药后3天仍有显著剂量率。还收集了16例患者给药后24天内的所有尿液。氯化铊-201的尿排泄率缓慢；注射后24小时内约2%的活度排出。锝-99m甲氧基异丁基异腈的尿排泄迅速，注射后数小时内大量活度排出；注射后20小时内排出22%。