Heinemann L, Krämer U, Klötzer H M, Hein M, Volz D, Hermann M, Heise T, Rave K
Profil Institute for Metabolic Research GmbH, Neuss, Germany.
Diabetes Technol Ther. 2000 Summer;2(2):211-20. doi: 10.1089/15209150050025168.
Continuous glucose monitoring by means of optical glucose sensors would allow patients with diabetes to check their metabolic control to their convenience. In an earlier study, we showed that noninvasive glucose monitoring is feasible for rapid changes in blood glucose by means of measuring the scattering coefficient of human skin. In this study, we investigated whether also slower changes in blood glucose, this time induced by an oral glucose load, can also be monitored by this approach.
Five healthy subjects and 13 patients with type 2 diabetes have been given a 75-g oral glucose load. Portable noninvasive systems were used to measure the skin tissue scattering coefficient. For this purpose, two optical sensor heads were attached directly to the skin of each volunteer. Light was applied to the skin and the reflected light intensity was registered.
In 8 of 10 measurements, correlation of changes in scattering coefficient with changes in glycemia was acceptable. In 19 of 26 measurements (73%) of patients with type 2 diabetes the observed changes in the scattering coefficient also correlated in acceptable manner. The accordance between the simultaneous measurements of the two sensor heads was acceptable in 13 of 18 volunteers and patients studied. There were virtually no differences in the quality of the measurements between healthy volunteers and patients with diabetes.
This study shows that also slow changes in blood glucose induced by an oral glucose load can be monitored by registration of scattering coefficient changes. It remains to be elucidated why this has not been possible in all experiments.
通过光学葡萄糖传感器进行连续血糖监测可让糖尿病患者在方便的时候检查自身的代谢控制情况。在早期研究中，我们表明通过测量人体皮肤的散射系数，无创血糖监测对于血糖的快速变化是可行的。在本研究中，我们调查了由口服葡萄糖负荷引起的血糖较慢变化是否也能通过这种方法进行监测。
给5名健康受试者和13名2型糖尿病患者口服75克葡萄糖负荷。使用便携式无创系统测量皮肤组织散射系数。为此，将两个光学传感器头直接连接到每个志愿者的皮肤上。向皮肤照射光线并记录反射光强度。
在10次测量中的8次，散射系数变化与血糖变化的相关性是可接受的。在2型糖尿病患者的26次测量中有19次（73%），观察到的散射系数变化也具有可接受的相关性。在所研究的18名志愿者和患者中，两个传感器头的同步测量结果在13例中是可接受的。健康志愿者和糖尿病患者之间的测量质量几乎没有差异。
本研究表明，通过记录散射系数变化也可以监测由口服葡萄糖负荷引起的血糖缓慢变化。为何并非在所有实验中都能做到这一点仍有待阐明。
