Strobel H W, Thompson C M, Antonovic L
Department of Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, 77225, USA.
Curr Drug Metab. 2001 Jun;2(2):199-214. doi: 10.2174/1389200013338577.
The presence and activity of cytochromes P450 in brain regions and various brain cells have been extended and advanced over the last five years covered by this review. Using in situ hybridization and immunohistochemical techniques, many cytochrome P450 enzymes have been demonstrated to be present in brain and to have a regional rather than universal distribution. Many of these various cytochromes P450 have been shown to catalyze the metabolism of neurosteroids as well as other biologically significant compounds in brain. In addition, many cytochrome P450 enzymes have been implicated in the metabolism of psychoactive drugs such as neuroleptics and antidepressants. The regulation of cytochrome P450 expression has been studied at greater detail, the regulation of aromatase being a prominent example during the last five years.
在本综述涵盖的过去五年中，细胞色素P450在脑区和各种脑细胞中的存在及活性研究有了进一步拓展和进展。运用原位杂交和免疫组化技术，已证实许多细胞色素P450酶存在于脑中，且具有区域分布而非普遍分布的特点。已表明这些各种各样的细胞色素P450中的许多酶能够催化脑内神经甾体以及其他具有生物学意义的化合物的代谢。此外，许多细胞色素P450酶还参与了精神活性药物如抗精神病药和抗抑郁药的代谢。细胞色素P450表达的调控已得到更深入的研究，过去五年中芳香化酶的调控就是一个突出的例子。
