Borghi C, Veronesi M, Prandin M G, Dormi A, Ambrosioni E
Divisione di Medicina Interna, Policlinico S. Orsola, Via Massarenti 9, 40138 Bologna, Italy.
Curr Hypertens Rep. 2001 Aug;3(4):281-8. doi: 10.1007/s11906-001-0090-y.
Hypertension and high serum cholesterol levels are two of the most relevant risk factors for cardiovascular diseases. A combined increase in both risk factors has been reported in a significant proportion of patients with coronary artery disease. Statins are the most widely used drugs to treat hypercholesterolemia, and they interact with blood pressure control in different populations of hypertensive patients. A significant reduction in blood pressure associated with the use of statins has been described in patients with untreated hypertension and in patients treated with antihypertensive drugs, particularly angiotensin converting enzyme inhibitors and calcium channel blockers. The effect of statins on blood pressure control has also been reported in diabetic patients. The mechanisms responsible for the hypotensive effect seem to be largely independent of the effect of statins on lipid profile, and are probably related to their interaction with endothelial function or angiotensin II receptors. The capacity of statins to improve blood pressure control could be a useful consideration for an integrated approach to better prevention of cardiovascular diseases.
高血压和高血清胆固醇水平是心血管疾病最相关的两个危险因素。在相当比例的冠心病患者中，已报告这两种危险因素同时升高。他汀类药物是治疗高胆固醇血症最广泛使用的药物，它们在不同人群的高血压患者中与血压控制相互作用。在未经治疗的高血压患者以及接受抗高血压药物（特别是血管紧张素转换酶抑制剂和钙通道阻滞剂）治疗的患者中，已描述使用他汀类药物可使血压显著降低。在糖尿病患者中也报告了他汀类药物对血压控制的作用。导致降压作用的机制似乎在很大程度上独立于他汀类药物对血脂谱的作用，并且可能与其与内皮功能或血管紧张素II受体的相互作用有关。他汀类药物改善血压控制的能力可能是更好地预防心血管疾病综合方法的一个有用考虑因素。
