Casey D E, Denny D
Am J Psychiatry. 1975 Aug;132(8):864-7. doi: 10.1176/ajp.132.8.864.
A patient who developed severe tardive dyskinesia after the termination of long-term phenothiazine therapy was successfully treated with deanol, a possible precursor of acetylcholine. Physiological measurements were obtained to quantify the clinical course. The authors discuss the practical and heuristic implications of these observations and suggest further consideration of therapy directed toward enhancement of cholinergic activity in the central nervous system.
一名患者在长期使用吩噻嗪类药物治疗结束后出现严重迟发性运动障碍，使用可能是乙酰胆碱前体的二甲氨基乙醇成功治愈。通过生理测量来量化临床病程。作者讨论了这些观察结果的实际意义和启发意义，并建议进一步考虑针对增强中枢神经系统胆碱能活性的治疗方法。
