Widroe H J, Heisler S
Dis Nerv Syst. 1976 Mar;37(3):162-4.
The pathogenesis of tardive dyskinesia is distinct from and may be functionally opposite to that of parkinsonism. The former is thought to be related to central nervous system dopaminergic hyperactivity, while the latter is known to be related to dopamine deficiency. An effective schema for the treatment of tardive dyskinesia includes avoiding antiparkinsonian medication and prescribing deanol, an acetylcholine precursor, while continuing or increasing phenothiazine dosages.
迟发性运动障碍的发病机制与帕金森病不同，在功能上可能相反。前者被认为与中枢神经系统多巴胺能亢进有关，而后者已知与多巴胺缺乏有关。治疗迟发性运动障碍的有效方案包括避免使用抗帕金森药物，并开具乙酰胆碱前体二甲氨基乙醇，同时继续或增加吩噻嗪的剂量。
